Biostem announces agreement to acquire one of the largest stem cell companies in the united states.

 

Atlanta --  November 28, 2005.  On November 22, 2005, BioStem, Inc. (Nasdaq OTC: BTEM) entered into an Agreement and Plan of Merger with Cryobanks International, Inc., a Delaware corporation (ÒCryobanksÓ). 

 

Pursuant to the terms of the Merger Agreement, BioStem will divest itself of its two operating subsidiaries, and will have no more than $25,000 of accrued but unpaid liabilities on the effective date of the merger.  On the effective date of the merger, BioStem will issue 120,000,000 shares of its common stock to the shareholders of Cryobanks, and the board of directors of Cryobanks will be appointed to BioStemÕs board, and the current members of BioStemÕs board will resign. 

 

Immediately prior to the effective date of the merger, approximately 159,150,044 currently outstanding shares of BioStem held by BioStem management and five unrelated shareholders, will be cancelled in exchange for the transfer by BioStem of all of the common stock of its current two operating subsidiaries, BH Holdings, Inc. and ABS Holdings, Inc. to such shareholders  Accordingly, immediately prior to the merger, BioStem will have 15,650,000 shares of common stock outstanding, and warrants to purchase 2,000,000 shares of common stock with an exercise price of $1.00 per share.

 

A condition to the effectiveness and closing of the merger is the successful completion of a financing by Cryobanks which results in net proceeds to Cryobanks of at least $10.0 million.  Half of the proceeds of such financing will be used to retire certain preferred stock of Cryobanks, and the balance for working capital and general corporate purposes.  Cryobanks will issue securities which will be convertible into approximately 10,000,000 shares of BioStem common stock, and warrants to purchase 3,000,000 shares of BioStem common stock at $1.10 per share, on the effective date of the merger, although Cryobanks has the option of increasing the financing by as much as 15%.  Accordingly, after the merger and assuming its successful closing, there will be approximately 145,650,000 shares of BioStem outstanding, plus warrants to purchase a total of 5,000,000 shares at $1.00 to $1.10 per share, and Cryobanks will be a wholly-owned subsidiary of BioStem.    

 

The boards of directors of both BioStem and Cryobanks have approved the merger agreement, and the majority shareholders of both companies have consented to the merger agreement. 

 

About Cryobanks:

 

Cryobanks International, Inc. is a leader in the collection, processing, and banking of stem cells derived from the umbilical cord immediately after birth, and with a current cord blood bank inventory of over 8,500 units, plus over 1,000 research units, Cryobanks believes it has the largest cord blood bank of any private company in the United States.  The units of cord blood are processed and stored by Cryobanks for use in unrelated transplants (where the donor is a histocompatible match, but is anonymous and unrelated to the recipient) and for personal storage and use.  Cryobanks intends to become the largest provider of cord blood stem cells (CBSCs) for transplant and research purposes in the world.

 

Cryobanks is engaged in three core businesses, all related to Cord Blood collection, storage and use.  The first business is the collection and storage of Cord Blood units of donated by the parents at birth for unrelated cord blood transplants (ÒDonor UnitsÓ).  While Cryobanks bears the cost of collection and processing, these Donor Units have three distinct uses for therapeutic purposes: for Cord Blood transplant, for research in the discovery of new therapeutics, and for sale of the stem cells for other research purposes.  Currently, Cryobanks lists its unrelated transplantable units on three key worldwide registries.

 

The second business involves the collection of Cord Blood units for personal storage, to be used, if necessary, by the donor family or its designees.  In this case, the donating family pays for collection, processing and storage, plus an annual fee for continued storage. 

 

The third business involves technology licensing.  Cryobanks has been asked by many international groups to help them set up Cord Blood collection and storage facilities.  Cryobanks has developed a model for assisting other parties in this endeavor and already has agreements to assist in the formation of several facilities, seven in India and one in Greece.  The Athens, Greece location will be operational in 2005. The first Indian facility located in New Delhi will be operational in May of 2006.  The next six Indian locations will open over the course of the following twenty-four months. Cryobanks estimates that it can assist the development of four to six foreign facilities each year for which it will receive a large up-front cash fee plus a percentage of the gross revenues of each facility. 

 

Cryobanks will also use donated cord blood units for research purposes.  Cryobanks expects to help sponsor research in areas related to stem cell therapy.  In return, Cryobanks will have first rights to licensing and royalty income when and if the therapies based on this research are developed.  Cryobanks has signed one Material Transfer Agreement with a well-known cancer research center and has four other agreements pending. Additionally, Cryobanks expects to secure a major research project to be conducted in Israel.

 

Cryobanks has entered into, or is currently negotiating several research projects and other opportunities.  Additional agreements are in the areas of neural, spinal cord, and heart repair using stem cells.  In addition, Cryobanks has identified opportunities for growth and expansion via acquisition of other Cord Blood programs or technology which could lead to significant acceleration of growth and revenues.  For example, as of September 2004, the National Marrow Donor Program (NMDP) has agreed to serve as the Institutional Review Board (IRB) for Cryobanks which is expected to greatly facilitate the use of its donor cord blood samples in clinical settings.

 

Cryobanks International represents a unique established facility involved in technology that has the potential to be highly profitable and can provide substantial income and also enter diversified yet related businesses.  In addition, management hopes that the expanded Company activities will be directly responsible for the saving of lives and discovery of new therapies.

 

Cryobanks is accredited by the American Association of Blood Banks, New York State licensed, and FDA registered.  Cryobanks also holds memberships in the American Association of Bioanalysts and American Association of Tissue Banks.  Currently, Cryobanks is the only facility accepting donated cord blood units from anywhere in the continental United States, every day of the week.  This effort is leading to CryobanksÕ goal of developing the largest database of quality transplantable cord blood stem cell units worldwide.  It is the mission of Cryobanks to ensure that anyone in need of a cord blood stem cell transplant will have a matched unit to access.

 

Cryobanks strives to be the leading bank for stored Cord Blood in the world.  Cryobanks believes that the potential markets for CBSCs and related products, services and technologies are large.  With its background, personnel, technological know-how, and facilities, Cryobanks is in the unique position of being able to address multiple business opportunities – all related to CBSCs.

 

It is important to note that Cryobanks does not use stem cells derived from fetal (embryonic) tissue and is therefore not subject to the many ethical and emotional issues surrounding fetal stem cell research.  Cryobanks uses only stem cells obtained from umbilical cords.

 

Cryobanks has already placed about 8,585 units on various registries and expects very substantial growth in the number of units in its cord blood bank. 

 

The description transactions contained in this press release, and the description of Cryobanks, are qualified in their entirety by reference to the Current Report on Form 8-K filed with the SEC, which can be obtained by visiting the SECÕs website at http://www.sec.gov/edgar/searchedgar/companysearch.html.

 

Safe Harbor Statement

This press release contains "forward looking statements."  These statements relate to future events or our future financial performance and transactions, and involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements, to be materially different from those contemplated by the forward looking statements.  There can be no assurance that the acquisition described herein will successfully close.  We undertake no ongoing obligation, other than that imposed by law, to update these statements.  Factors that could affect our results, levels of activity, performance or achievements and cause them to materially differ from those contained in the forward looking statements include the failure of Cryobanks to complete its financing, and other factors that can be found in our filings with the Securities and Exchange Commission, including our annual reports on Form 10-K, current reports on Form 8-K and quarterly reports on Form 10-Q, as amended.